In an effort to comply with the most recent directives regarding covid19 by Pennsylvania Governor Tom Wolf, Penn State University President Eric Barron and the Office of the Senior Vice President for Research, all Shriver Lab research activities have been put on hold until further notice.
All human subjects research projects performed by our lab have been halted. This will likely result in delays to research participants receiving their incentives until the current restrictions are lifted and research activities can resume as normal. If you have any questions regarding your incentives or the status of our research please contact us using the information below. Research staff will respond to your inquires within 48 hours.
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Carrie L. Pfaff is working on computer simulations of the admixture process to better understand the dynamics and the statistical power that will be present for mapping chonic diseases. Admixture mapping simulations provide a review of her project and a look at some recent results.
Verified and well-classified AIMs
All molecular and frequency information on the Ancestry Informative Markers that we have characterized have been submitted to dbSNP and are posted on the NCBI web site at NIH under the submitter handle PSU-ANTH. Click on the following link to be transfered to this site.
PSU-ANTH markers in dbSNP
Candidate AIMs: Allele frequencies from Akey et al. 2002
We have recently analyzed allele frequency data from the TSC on 26,000 SNPs. The first analysis of this data will be published in Genome Research in December 2002. Click on the link below to download the file with the allele frequencies and delta levels for the markers summarized in this work.
26,000 SNPs in 3 populations
Measuring European Population Stratification using Microarray Genotype Data
Bauchet M, McEvoy B, Pearson LN. , Quillen EE. , Sarkisian T, Hovhannesyan K, Deka R, Bradley DG, Shriver MD. 2007. American Journal of Human Genetics 80(May):948-956.
Am J Hum Genet 1998 Dec;63(6):1839-51
Estimating African American admixture proportions by use of population-specific alleles.
Parra EJ, Marcini A, Akey J, Martinson J, Batzer MA, Cooper R, Forrester T, Allison DB, Deka R, Ferrell RE, Shriver MD Department of Human Genetics, Allegheny University of Health Sciences, Pittsburgh, Pennsylvania, USA.
We analyzed the European genetic contribution to 10 populations of African descent in the United States (Maywood, Illinois; Detroit; New York; Philadelphia; Pittsburgh; Baltimore; Charleston, South Carolina; New Orleans; and Houston) and in Jamaica, using nine autosomal DNA markers. These markers either are population-specific or show frequency differences >45% between the parental populations and are thus especially informative for admixture. European genetic ancestry ranged from 6.8% (Jamaica) to 22.5% (New Orleans). The unique utility of these markers is reflected in the low variance associated with these admixture estimates (SEM 1.3%-2.7%). We also estimated the male and female European contribution to African Americans, on the basis of informative mtDNA (haplogroups H and L) and Y Alu polymorphic markers. Results indicate a sex-biased gene flow from Europeans, the male contribution being substantially greater than the female contribution. mtDNA haplogroups analysis shows no evidence of a significant maternal Amerindian contribution to any of the 10 populations. We detected significant nonrandom association between two markers located 22 cM apart (FY-null and AT3), most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations. The strength of this association and the substantial genetic distance between FY and AT3 emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental populations.
PMID: 9837836, UI: 99057521